Stress & aging
What chronic stress actually does to the body.
The acute stress response is not the problem — it is fast, useful, and self-limiting. The damage comes from a response that never fully switches off. Three mechanisms carry most of that cost.
Cortisol
A rhythm that flattens
Healthy cortisol has a steep daily curve: a sharp rise 30 minutes after waking, then a long decline into the evening. Under sustained stress that slope flattens — lower peaks, higher nights. A flattened diurnal slope has been associated with worse outcomes across a range of conditions, and it is one reason chronic stress and poor sleep are so hard to separate.
Inflammation
Low-grade, systemic, persistent
Prolonged stress shifts immune signalling toward a pro-inflammatory profile, with elevated IL-6 and CRP. This is the common pathway linking psychological stress to cardiovascular disease, metabolic dysfunction and depression — the same low-grade inflammation that features in most models of biological aging.
Allostatic load
The bill for staying switched on
McEwen's framing: the systems that protect you in the short term wear you down when they never stand down. Allostatic load is the cumulative cost across cardiovascular, metabolic, immune and neural systems — and it tracks the duration of the response far more closely than its peak.
Where HRV fits
Heart-rate variability is the beat-to-beat variation in the interval between heartbeats. A healthy heart is not a metronome: under parasympathetic (vagal) influence, the interval flexes constantly. Higher resting variability generally indicates a nervous system that can shift gears — up for demand, down for recovery.
Across research, higher HRV is associated with better self-reported sleep, lower fatigue and lower perceived stress, which is why it makes a useful cross-check on a self-report questionnaire. It is not a substitute for one. HRV varies enormously between individuals — by age, fitness, genetics, posture and measurement method — so the meaningful signal is your own trend over weeks, not your number against someone else's.